We need a new scientific framework to handle the immense complexity of the global issues we are facing. A new Centre has been founded to develop this scientific framework and to create new solutions by a close integration of social and technological innovation.The leading principle of the Centre is that the behaviour of complex systems can not be derived from their individual components only. Complex systems need also be studied as a whole. This should be done by collecting multifaceted datasets ('big data sensing'), followed by 'big data analytics'. The larger the complexity, the less reliable our theoretical models and the more emphasis is needed on collecting measurements ('let the data speak'). For more information see www.cfgsec.com.